InsighT, InsighT-Adv & InsighT Plus are Non-Invasive Prenatal Screening tests also called cell-free fetal DNA (cffDNA) tests offered exclusively by Lilac Insights.
These are the screening tests for common chromosomal disorders with an accuracy or detection rate of >99% for Trisomy 21, Trisomy 18 and Trisomy 13. These tests analyze the DNA of the fetus also called cffDNA which begins to circulate in the mother’s blood after 7-8 weeks of gestation.
InsighT/ InsighT-Adv/ InsighT Plus can be done from the 10th week onwards to ensure enough cffDNA is available in the mother’s blood stream to get accurate reports.
InsighT, InsighT-Adv & InsighT Plus are screening tests for common chromosomal aneuploidies, sex chromosomal aneuploidies and other microdeletions & duplications.
InsighT & InsighT-Adv are the only Advanced Non-invasive prenatal screening (NIPS) tests in India which use an innovative, patented technology called ‘Target Capture Enrichment Technology’ (TACS) developed by NIPD Genetics to isolate & analyse the cell-free DNA from maternal plasma.
TACS technology is specifically designed to overcome problems associated with other NIPTs and to increase the precision and accuracy through InsighT & InsighT-Adv tests. Both these tests have been clinical validated for the conditions reported by them and thereby deliver unmatched clinical performance.
Get an insight about what does these tests detect in the table below.
|Test||Common Chromosomal Aneuploidies (T21, T18, T13)||Other Common Chromosomal Aneuploidies (T9, T16, T22)||Sex chromosomal Aneuploidies (Aneuploidies* X, Y)||Microdeletions & Duplications|
|Twin/Vanished twin Pregnancy||--||--||--|
|Singleton Pregnancy||--||4 microdeletions- DiGeorge syndrome (22q11.2 deletion), 1p36 deletion, Smith-Magenis syndrome (17p11.2 deletion), Wolf-Hirschhorn syndrome (4p deletion)|
|Twin/Vanished twin Pregnancy||--||--|
|Singleton Pregnancy||63 deletion, duplication & microdeletions|
*Sex chromosome aneuploidies cannot be screened in twin and vanished twin pregnancies.
Note: Sex of the fetus is not determined/ reported by Lilac Insights as per PC-PNDT Act, 2003
These are advanced prenatal screening tests exclusively offered by Lilac Insights using advanced and patented technology. The test is conducted on pregnant woman’s blood sample whose pregnancy maybe at a high risk of carrying a fetus with most common genetic abnormalities.
These tests give expecting parents Peace of Mind by providing early and accurate information about the health of their unborn baby with respect to chromosomal abnormalities in advance.
Opting for InsighT/ InsighT-Adv/ InsighT Plus (NIPS) from Lilac Insights, will help you to take confident decisions about your further pregnancy management.
In principle, all these tests analyze the cell-free fetal DNA (cffDNA) present in mother’s blood.
In terms of technology, InsighT and InsighT-Adv utilize the latest patented TACS technology (developed by our technology partner, NIPD Genetics) while InsighT Plus uses Whole Genome Sequencing technology-based Massively Parallel Sequencing technique both of which are proven latest technologies.
These tests differ in the genetic conditions/ abnormalities which they can detect.
Both these are performed on maternal/ mother’s blood sample.
InsighT range of tests analyses the DNA of the fetus that is circulating in the mother’s blood whereas biochemical marker test (Dual/Triple/Quadruple marker) analyses the levels of certain pregnancy associated hormones in the mother’s blood during the certain period of pregnancy.
Another difference between these two types of tests is the detection rate: InsighT / InsighT-Adv/ InsighT Plus offers >99% detection rate for common chromosomal abnormalities whereas the detection rate for biochemical marker screening ranges between 65 to 90%, for common chromosomal abnormalities, depending on the screening protocol chosen.
InsighT range of NIPS screening test can screen for more chromosomal abnormalities than the conditions screened by biochemical screening options.
InsighT range of tests can provide a reassurance in case of the fetus being affected by a genetic disorder.
These tests can be performed as early as 10 weeks of pregnancy depending of the pregnancy type (Singleton/Twin/Vanishing twin).
You can opt for a pre-test counselling with our prenatal genetic counsellor to understand the need and importance of the test.
These tests require 10 ml of peripheral blood of pregnant woman in a specialized tube (Streck tube) post 10 weeks of pregnancy. Sample can be drawn by any trained phlebotomist in preferred clinic*
*PC-PNDT registered clinic/ center/ hospital.
There is no risk associated with NIPS testing for fetus or mother, as the test is performed on mother’s regular blood sample.
*A minor redness or swelling can appear at the spot of blood collection in rare case which can be managed easily.
These tests reveal a risk assessment as either High risk or Low risk for a particular or more than one genetic condition that they each cover.
In few cases, resampling may be required to ensure the quality control parameters are met. Such resampling is offered at no extra cost.
In rare cases, test failure report may be delivered to you because certain quality parameters are not matched during testing such as low amount of cell-free fetal DNA in the sample. In these cases, money collected from you will be refunded to you after deducting specimen handling and processing charges.
If an InsighT/ InsighT-Adv / InsighT Plus test report a high risk for a particular condition, the second step is to go for diagnostic testing i.e. Confirmatory Tests after consultation with your doctor & prenatal genetic counsellor.
Confirmatory prenatal diagnosis involves analysis of amniocytes or chorionic villi to confirm whether the fetus is affected with the chromosomal abnormality or not.
*No clinical decisions should be solely based on any screening results unless the diagnosis has been ascertained.
Low risk results imply that the probability of your pregnancy being affected with the screened genetic abnormalities is very low. For more information: You can opt for a pre-test/ post test counselling with our prenatal genetic counsellor or consult your doctor.
Confirmatory tests which check for chromosomal abnormalities require samples of fetus obtained through invasive procedures. Though these invasive procedures are performed by experts, still there is a risk of miscarriage due to the innate nature of the procedure. InsighT/ InsighT-Adv / InsighT Plus helps identify those pregnancies which are at a high risk of having a chromosomal abnormality & hence warrant an invasive test. The pregnancies that are reported as low risk by InsighT/ InsighT-Adv/ InsighT Plus need not be exposed to undue harm by doing an invasive procedure.
Ideally, InsighT/ InsighT-Adv/ InsighT Plus can be offered for all pregnancies based on the eligibility criteria to know the health of their fetus.
Ideally you should be screened for the most common & widespread clinically relevant genetic disorders which have been included in these tests to reduce your unwanted anxiety.
In addition, if there is any family/previous pregnancy history of any specific genetic disorder then you will require additional tests specific to those disorders which your consulting doctor will decide.
In most cases, your referring doctor will ask you to do these tests from Lilac Insight. But in case your doctor who isn’t familiar with Lilac Insights, you can Contact Us & we will facilitate the process.
Normally one screening is all that is required. In few cases, especially for patients with high risk/ intermediate risk results from biochemical screening, your doctor may suggest you to undergo NIPS as a reassuring test before opting an invasive confirmatory Test.
A trained phlebotomist or a nursing staff member can draw the sample for the test.
InsighT/ InsighT-Adv/ InsighT Plus tests are specialized genetic tests.
In routine test such as hemoglobin test, fixed ranges or cutoffs are used to provide reports while InsighT/ InsighT-Adv/ InsighT Plus (NIPS) screening requires in depth advanced genetic analysis for each case.
Lilac Insights being advanced dedicated genetic diagnostic center is well equipped with technologies and experts to conduct & provides accurate reports to clinicians and patients.
InsighT/ InsighT-Adv/ InsighT Plus tests are exclusively offered by Lilac Insights. As these NIPS testing requires specialized technology and expertise, they should be performed at specialized laboratories such as Lilac Insights to ensure the confident and reliable reports. Such laboratory should be registered under the PCPNDT act of India.
In most cases, the referring doctor decides where to send these NIPS/NIPT samples.
Being market leaders, there is a high chance that your doctor may be already using Lilac Insights’ genetic testing services. You may discuss this with your doctor & upon mutual agreement, provide us with the contact details. We will get in touch with the concerned person & facilitate the process.
Your doctor should be able to address all your questions. You may feel free to get in touch with our Genetic counselors if you wish to understand more about the test and its results. Click here for e-Genetic Consultation & Counseling.
The report is generally sent within 10-12 working days after arrival of blood sample at the processing center. A digital report copy is also sent to you doctor over email (if email-ID has been provided).
These advanced genetic NIPS tests are available pan-India at reasonable and affordable cost. For pricing related queries you can contact your doctor or Local Lilac Insights representative or you can also call us at +91 22 4184 1438.
You can simply talk to your consulting Obstetrician or Gynecologist or Fetal medicine expert. As Lilac Insights is a market leader, there is high chance that your doctor is already availing any of our services. If your doctor is not familiar with Lilac Insights, you may provide us with your doctor’s details & we will get in touch with them to facilitate your NIPS testing.
You may also Contact Us & we will guide you through the process.
You may discuss this with your doctor & upon mutual agreement, provide us with the contact details. We will get in touch with the concerned person & facilitate the process. Being market leaders, there is a high chance that they are already working with us.
InsighT/ InsighT Plus reports give you a risk assessment of the fetus being genetically abnormal or not.
Your doctor should be able to address all your questions. You may feel free to get in touch with our Genetic counselors if you wish to understand more about the test and its results.
Click here for Genetic Consultation & Counseling.
Screening normally takes about 10 working days post arrival of blood sample at the lab. Your doctor should have a digital report by the end of the second week.
All pricings will be provided by your referring doctor.
For getting a screening done, the simplest way is to speak to your consulting Obstetrician or Gynecologist. As Lilac Insights is a market leader, there is a good chance they are already availing one of our services. In the event your doctor is not familiar with Lilac Insights, upon mutual discussion you may provide us with your doctor’s details & we will get in touch with them to facilitate the process.
You may also Contact Us directly & we will guide you through the process.